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KMID : 0043320100330020209
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Archives of Pharmacal Research
2010 Volume.33 No. 2 p.209 ~ p.214
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Anthraquinones from the Roots of Knoxia valerianoides Inhibit the Formation of Advanced Glycation End Products and Rat Lens Aldose Reductase In Vitro
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Kim Jin-Sook
Yoo Nam-Hee
Jang Dae-Sik
Lee Yun-Mi
Jeong Il-Ha
Cho Jung-Hee
Kim Joo-Hwan
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Abstract
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Eight known compounds, lucidin (1), lucidin-ω-methyl ether (2), rubiadin (3), damnacanthol (4), 1,3,6-trihydroxy-2-methoxymethylanthraquinone (5), 3,6-dihydroxy-2-hydroxymethyl-9,10-anthraquinone (6), 1,3,6-trihydroxy-2-hydroxymethyl-9,10-anthraquinone 3-O-β-primeveroside (7), and vanillic acid (8), were isolated from EtOAc- and n-BuOH-soluble fractions of the roots of Knoxia valerianoides. The structures of 1-8 were identified by analysis of spectroscopic data as well as by comparison with published values. All the isolates were subjected to in vitro bioassays to evaluate advanced glycation end products (AGEs) formation and rat lens aldose reductase (RLAR) inhibitory activity. Compound 5 showed the most potent inhibitory activity (IC50 = 52.72 μM) against AGEs formation. Compounds 1, 2, and 8 also showed potent inhibitory activity on AGEs formation with IC50 values of 79.28, 62.79, and 93.93 μM, respectively, compared with positive control, aminoguanidine (IC50 = 962 μM). While, compounds 1 and 5-7 showed strong inhibitory activity against RLAR with IC50 values of 3.35, 3.04, 6.39, and 2.05 μM, respectively.
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KEYWORD
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Knoxia valerianoides, Anthraquinones, Advanced glycation end products (AGEs), Rat lens aldose reductase (RLAR), Diabetic complications
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